This qualitative study presents practices associated with sustained youth engagement at 13 Latinx-serving youth development programs located in 3 California counties: 1 rural, 1 suburban and 1 urban. Empirical findings reflect 5 key dimensions of practice: (a) integrate extended understandings of positive youth development, (b) support positive ethnic identity development, (c) contend with physiological and social effects of discrimination, (d) respond to the ramifications of economic poverty, and (e) act upon the diversity of local and regional Latinx experience. Study findings translate into guiding principles that youth development programs are encouraged to operationalize based on local interests, needs, and resources.