USAID has adopted several comprehensive and interlinked policies and strategies to reduce gender disparities; eliminate gender-based violence; advance structural changes and promote equitable gender norms; and increase the capability of women and girls in all their diversity to fully exercise their rights, determine their life outcomes, assume leadership roles, and influence decision-making in households, communities, and societies. This Automated Directives System (ADS) chapter explains how to implement these policies and strategies across the Program Cycle, with a particular focus on applying analytic rigor to strengthen evidence-based decision-making and support for local ownership and the priorities of local actors and stakeholders. It also elaborates on the requirements in ADS 201, Program Cycle Operational Policy for integrating gender equality and women’s empowerment in all phases of programming, budgeting, and reporting. This ADS chapter, which is based on USAID’s Gender Equality and Women’s Empowerment Policy, applies to all Bureaus, Missions, and Independent Offices and covers policy and operations in Washington and the field. The requirements support USAID’s implementation of the Women's Entrepreneurship and Economic Empowerment (WEEE) Act of 2018 (P.L. 115-428). USAID must fully comply with the WEEE Act, which requires that: (1) strategies, projects, and activities of the Agency are shaped by a gender analysis; (2) standard indicators are used to assess such strategies, projects, and activities, if applicable; and (3) gender equality and women’s empowerment are integrated throughout the Agency's program cycle and related processes for purposes of strategic planning, project design and implementation, monitoring, and evaluation.