Youth, as our future leaders, will spearhead global efforts to improve health, education, economic development, and other outcomes. In October 2012, the United States Agency for International Development (USAID) launched the Youth in Development Policy, the first of its kind at USAID. The Policy recognizes that youth leadership is one of the many critical pathways for improved health and development for youth. However, there is not much knowledge about what constitutes effective youth leadership programming, particularly where these programs relate to public health initiatives. On the other hand, many programs conduct one off workshops on youth leadership without providing good followup, mentors, or an enabling environment for young people to apply their leadership skills. USAID, in collaboration with the Leadership, Management and Governance (LMG) Project, conducted a global review to identify and examine effective youth leadership programs, models, and strategies from around the world that have demonstrated positive outcomes for youth, organizations, and communities, and contribute to health service delivery improvements.