At the 2016 International AIDS Conference, three studies led by the Centre for the AIDS Programme of Research in South Africa (CAPRISA) provided important new evidence on the biological and structural factors that contribute to the high HIV burden among young women and girls. On Tuesday, November 15, 2016, CHANGE hosted an interactive webinar with CAPRISA director, Professor Salim Abdool Karim, who discussed this groundbreaking new research and implications for the future of HIV prevention for girls and young women.